Table 2 Demographics of the Lund cohort.

From: A multicentre validation study of the diagnostic value of plasma neurofilament light

  

Cognitively unimpaired

Cognitive impairment

Parkinsonian

Characteristics

CU Aβ−

CU Aβ+ 

SCD Aβ−

SCD Aβ+ 

MCI Aβ−

MCI Aβ+ 

EOAD

AD

FTD

PDD/DLB

VaD

PD

CBS/PSP

MSA

Number

1464

273

103

134

75

115

165

23

134

150

46

22

171

24

29

Age, years, mean (SD)

70 (7.1)

72 (6.5)

73 (5.5)

69 (5.7)

72 (5.3)

69 (5.6)

72 (4.5)

59 (3.5)

75 (5.2)

64 (8.8)

73 (6.9)

64 (5.7)

65 (10.7)

72 (4.4)

76 (4.4)

Female, n (%)

734 (50.1)

160 (58.6)

64 (62.1)

77 (57.5)

32 (42.7)

36 (31.3)

79 (47.9)

14 (60.9)

79 (59.0)

77 (51.3)

15 (32.6)

13 (44.8)

63 (36.8)

15 (62.5)

10 (45.5)

APOE e4 carriers, n (%) [missing]

507 (40.4) [210]

46 (17.1) [4]

65 (63.1) [0]

33 (24.8) [1]

48 (64.0) [0]

27 (23.5) [0]

116 (70.3) [0]

6 (54.5) [12]

81 (66.4) [12]

 

18 (41.9) [3]

9 (45.0) [2]

44 (29.9) [24]

7 (35.0) [4]

6 (22.2) [2]

MMSE, mean (SD) [missing]

26.8 (3.8) [96]

29.0 (1.1) [2]

28.8 (1.1) [0]

28.7 (1.3) [4]

28.2 (1.6) [5]

27.3 (1.9) [2]

26.8 (1.8) [4]

20.6 (4.5) [1]

21.3 (4.0) [3]

23.3 (5.8) [51]

22.3 (3.9) [7]

22.3 (4.5) [11]

28.0 (2.0) [0]

25.5 (4.5) [4]

27.2 (2.7) [2]

UPDRS-III [missing]

33.75 (15.1) [49]

         

34.4 (14.7) [20]

 

16.9 (10.4) [23]

41.9 (18.5) [4]

41.8 (22.1) [2]

Hoehn & Yahr scale [missing]

3.2 (0.9) [49]

         

3.0 (0.8) [20]

 

1.9 (0.8) [23]

3.9 (1.0) [4]

3.9 (1.1) [2]

CSF Aβ42/Aβ40

0.10 (0.04)

0.13 (0.02)

0.06 (0.02)

0.13 (0.02)

0.06 (0.02)

0.13 (0.03)

0.06 (0.02)

0.06 (0.04)

0.07 (0.03)

N/A

0.11 (0.04)

0.13 (0.02)

0.12 (0.03)

0.11 (0.03)

0.08 (0.03)

CSF NfL

1321 (1158)

894 (515)

1107 (770)

935 (470)

1332 (887)

1599 (1495)

1549 (1162)

1066 (870)

1845 (1572)

4590 (1230)

1589 (1030)

1758 (794)

888 (640)

2577 (1345)

3435 (1280)

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