Table 1 Fold changes and q-values for the mRNAs mentioned in the results section of the main text pertaining to cell culture models analyzed by RNA-Seq.
From: HOXA13 in etiology and oncogenic potential of Barrett’s esophagus
Gene name | Fold change | q-value (multiple testing corrected p value) |
|---|---|---|
Forced HOXA13 in mESC confers a relative competitive advantage in multipotent cell cultures through upregulation of Nanog signaling and downregulation of Wnt signaling | ||
Sox2 | 1.43 | 0.01 |
Nanog | 1.47 | 0.00 |
Tbx3 | 3.53 | 0.00 |
Hesx-1 | 20.56 | 0.00 |
Dppa-1 | 64.95 | 0.00 |
Igf2 | 3.61 | 0.00 |
Wnt3 | 0.43 | 0.00 |
Wnt4 | 0.36 | 0.00 |
Wnt6 | 0.36 | 0.00 |
Wnt8a | 0.48 | 0.01 |
Sp8 | 0.12 | 0.00 |
Lef1 | 0.34 | 0.00 |
Tbxt | 0.41 | 0.00 |
Axin2 | 0.55 | 0.04 |
Fgf8 | 0.10 | 0.00 |
Cdx1 | 2.47 | 0.00 |
Grhl3 | 5.00 | 0.00 |
Vill | 1.87 | 0.00 |
Forced HOXA13 expression supports caudal epithelial functions and appears to promote proliferation in DE | ||
Sox17 | 12.55 | 0.00 |
Lgr5 | 5.39 | 0.00 |
Nanog | 0.20 | 0.02 |
Ezr | 2.20 | 0.00 |
Vill | 2.58 | 0.048 |
Krt19 | 2.34 | 0.00 |
Krt20 | 2.84 | 0.01 |
Igsf8 | 4.67 | 0.00 |
Gcnt3 | 3.51 | 0.00 |
Fgfr2 | 2.81 | 0.00 |
Nek2 | 2.35 | 0.01 |
HOXA13 downregulates the chromosome 1 epidermal differentiation complex, is pro-oncogenic, and conveys typical characteristics of the BE phenotype | ||
ANXA9 | 0.48 | 0.04 |
EVPL | 0.61 | 0.03 |
SCEL | 0.52 | 0.01 |
KLK7 | 0.42 | 0.01 |
EMP1 | 0.56 | 0.03 |
SERPINB13 | 0.38 | 0.00 |
DLL1 | 2.57 | 0.00 |
FURIN | 1.49 | 0.03 |
JAG1 | 1.85 | 0.04 |
