Fig. 7: Osteoclast-targeting delivery of functional motif of Nron increases bone mass in osteoporotic mice.
From: A functional motif of long noncoding RNA Nron against osteoporosis
a Representative Ī¼CT images showing the 3D bone structures of femurs from Sham, OVX, OVX-Vector, OVX-Zol, OVX-Nron, and OVX-NCM2 group, (similar results were obtained in all mice, nā=ā6/group). Scale bar: 1āmm. b Ī¼CT measurements of BV/TV, Tb.N, and Tb.Th in femurs from Sham, OVX, OVX-Vector, OVX-Zol, OVX-Nron, and OVX-NCM2 group, (nā=ā6/group). c Representative H&E staining images of femurs from Sham, OVX, OVX-Vector, OVX-Zol, OVX-Nron, and OVX-NCM2 group, (similar results were obtained in all mice, nā=ā6/group). Scale bar: 500āĪ¼m. d Representative TRAP staining images of femurs from Sham, OVX, OVX-Vector, OVX-Zol, OVX-Nron, and OVX-NCM2 group, (similar results were obtained in all mice, nā=ā6/group). Scale bar: 500āĪ¼m (upper panels); 100āĪ¼m (lower panels). e Histological measurements of BV/TV values in c, (nā=ā6/group). f Quantification of osteoclastic metrics Oc.N/B.Pm and Oc.S/BS in subepiphyseal region of femurs in d, (nā=ā6/group). Data are presented as the meansāĀ±ās.e.m. The significant differences between Sham/OVX-Vector/OVX-Zol/OVX-Nron/OVX-NCM2 treatment group with OVX group were determined by one-way ANOVA with Dunnettās multiple comparisons test. Source data are provided as a Source Data file.
