Fig. 4: Growth rate is different between the uxs1 suppressor strains in C. neoformans and C. gattii.
From: Moderate levels of 5-fluorocytosine cause the emergence of high frequency resistance in cryptococci
The doubling time of indicated strain is determined using a plate reader. a C1933 is a 5-FC sensitive strain derived from repeated transfers of WL8. b C1943 is a 5-FC sensitive strain derived from repeated transfers of WL9. C2030 is a strain containing UGD1G19A that was manually introduced into WL9. c C1952 is a 5-FC sensitive strain derived from repeated transfers of 13C2. C2050 and C2119 are suppressor strains obtained by molecular manipulations which contained Knrg1 and UGDG19A, respectively. The experiments were repeated at least three times (n ≥ 21) and data are presented as mean values ± standard deviation. One-way ANOVA with Tukey’s test for multiple comparisons (ns = not significant, and ****p < 0.0001).
