Fig. 1: Inhibition of the enzymatic activity of the SARS-CoV-2 3CLpro and the replication of SARS-CoV-2 in cells by myricetin and its derivatives. | Nature Communications

Fig. 1: Inhibition of the enzymatic activity of the SARS-CoV-2 3CLpro and the replication of SARS-CoV-2 in cells by myricetin and its derivatives.

From: Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease

Fig. 1

a Chemical structures of baicalein, myricetin, dihydromyricetin, and compounds 3, 7, 9, and 10. b Representative inhibition profiles for myricetin (blue), dihydromyricetin (orange), 3 (red), 7 (green), 9 (purple), and 10 (dark red) against the SARS-CoV-2 3CLpro. Error bars represent mean ± SD of three independent experiments. c Inhibition profiles of myricetin (blue), dihydromyricetin (orange), 3 (red), 7 (green), 9 (purple), 10 (dark red), and remdesivir (black) against the replication of SARS-CoV-2 in Vero E6 cells. Error bars represent mean ± SD of six independent experiments.

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