Fig. 7: TE1 and TE2 influence TAAR gene expression in cis not trans.
From: Olfactory expression of trace amine-associated receptors requires cooperative cis-acting enhancers
a Three genotypes used to test for trans effects of TAAR elements. TE1 and TE2 are shown (magenta). Deletions are indicated (X). Taar4-RFP targeted allele (red) is linked to the double deletion, ΔTE1/2. b Confocal images of representative olfactory epithelium sections showing RFP-labeled OSNs (red) in Taar4-RFP mice (left). Nuclei are labeled with TOPRO-3 (blue). No labeled OSNs are seen in homozygous (right) or heterozygous (middle) ΔTE1/2 mice (n = 3 mice per genotype). c Average number of RFP+ OSNs counted in 6 representative olfactory epithelium sections from Taar4-RFP (n = 4), ΔTE1/2 heterozygous mice (n = 3), and ΔTE1/2 homozygous mice (n = 3 mice). *p < 0.0001 two-sided, ANOVA with contrasts. Error bars indicate mean ± SEM. Scale bar = 50 µm.
