Fig. 4: The Multabody enhances the potency of human mAbs from phage display.
From: Multivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers
a Work flow for the identification of potent anti-SARS-CoV-2 neutralizers using the MB technology. Created with Biorender. b Comparison of neutralization potency between IgGs (cyan) and MBs (pink) that display the same human Fab sequences derived from phage display. c IC50 values fold increase upon multimerization. d Apparent affinity (KD), association (kon), and dissociation (koff) rates of the most potent neutralizing MBs (pink) compared to their IgG counterparts (cyan) for binding the SARS-CoV-2 S protein. Three biological replicates and their mean are shown for IC50 values in (b) and (c). Source data of panels b–d are provided as a Source Data file.
