Fig. 5: Decreased succinate accumulation contributes toward the onset of abortion in mice.
From: Low chorionic villous succinate accumulation associates with recurrent spontaneous abortion risk
a Succinate levels in cells treated with or without glycine (n = 5 biological repeats). b Succinate levels in villi of mice with various treatments (n = 5 biological repeats). c Embryo-resorption rates in mouse models with various treatments (n = 10 biological repeats). Representative macroscopic appearance of uteri on gestational day 13.5 in pregnancies with various treatments were shown in right panel. d SDHB expression levels in villi from mice with various treatments. e IL-1β expression levels in villi from mice after indicated treatments. f Embryo-resorption rates in mouse models with indicated treatments (n = 9 biological repeats). g Schematic illustration indicating how low embryonic villous succinate accumulation increases RSA risk. a–c, f Data represent the mean ± standard error, *P < 0.05, **P < 0.01, ***P < 0.001, ns not significant. Two-tailed unpaired Student’s t tests in a; one-way ANOVA in b, c, f. Source data are provided as a Source Data file.
