Table 1 Metabolite concentrations in villi from individuals with RSA or normal controls.

From: Low chorionic villous succinate accumulation associates with recurrent spontaneous abortion risk

Metabolites (μmol/g)

Normal (n = 30)

RSA (n = 30)

P value

Adjusted P value

Glucose

3.166 ± 0.893

3.257 ± 0.767

0.676

0.947

Pyruvate

0.306 ± 0.085

0.279 ± 0.09

0.251

0.828

Lactate

3.367 ± 1.221

2.881 ± 0.921

0.087

0.828

Citrate

0.303 ± 0.097

0.277 ± 0.085

0.282

0.828

Succinate

0.589 ± 0.121

0.429 ± 0.109

1.48 × 10−6

5.18 × 10−5

Fumarate

0.146 ± 0.05

0.174 ± 0.053

0.037

0.653

Phenylalanine

0.226 ± 0.048

0.212 ± 0.049

0.265

0.828

Tyrosine

0.209 ± 0.044

0.208 ± 0.061

0.910

0.992

Aspartate

1.598 ± 0.419

1.502 ± 0.484

0.413

0.828

Glutamate

2.088 ± 0.656

1.874 ± 0.684

0.221

0.828

Glutamine

2.821 ± 0.722

2.659 ± 0.731

0.391

0.828

Glycine

1.428 ± 0.589

1.367 ± 0.478

0.664

0.947

Valine

0.509 ± 0.121

0.509 ± 0.145

0.992

0.992

Isoleucine

0.273 ± 0.071

0.295 ± 0.107

0.370

0.828

Leucine

0.507 ± 0.113

0.516 ± 0.142

0.792

0.990

Histidine

0.182 ± 0.108

0.168 ± 0.098

0.594

0.945

Alanine

1.291 ± 0.298

1.223 ± 0.324

0.402

0.828

Acetate

0.294 ± 0.053

0.307 ± 0.072

0.426

0.828

Formate

0.362 ± 0.145

0.415 ± 0.214

0.264

0.828

Inosine

0.332 ± 0.192

0.315 ± 0.173

0.722

0.973

Creatine

1.062 ± 0.59

1.023 ± 0.503

0.784

0.990

Hypoxanthine

0.683 ± 0.233

0.63 ± 0.236

0.392

0.828

Carnosine

0.019 ± 0.012

0.019 ± 0.011

0.983

0.992

Uridine

0.338 ± 0.16

0.342 ± 0.17

0.932

0.992

Taurine

4.351 ± 2.288

3.778 ± 1.605

0.266

0.828

3-hydroxybutytrate

0.366 ± 0.304

0.371 ± 0.317

0.946

0.992

Nicotinamide

0.113 ± 0.071

0.11 ± 0.061

0.857

0.992

NAD

0.024 ± 0.011

0.021 ± 0.012

0.317

0.828

AMP

0.009 ± 0.008

0.009 ± 0.008

0.935

0.992

ADP

0.017 ± 0.011

0.016 ± 0.01

0.594

0.945

Uracil

0.25 ± 0.056

0.235 ± 0.068

0.355

0.828

  1. NAD nicotinamide adenine dinucleotide, AMP adenosine monophosphate, ADP adenosine diphosphate.
  2. Data presented are given in μmol/g (mean ± SD). P values were derived from unpaired two-sample t test (two groups have the same SD) or unpaired two-sample t test with Welch’s correction (two groups do not have the equal SD) and then corrected by using the Benjamini & Hochberg method for multiple sampling (adjusted P value). Source data are provided as a Source Data file.
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