Fig. 4: Myristic acid (C14:0) dominates the FFA response to AFC.
From: Saturated free fatty acids and association with memory formation
a, b Unsaturated and saturated FFAs in the central amygdala. Scatterplots show the AFC-induced absolute (y axis) and log2 fold change (x axis) in mean abundance for each FFA in saline- (round) and CPP- (square) treated animals. For all FFAs, CPP treatment resulted in a decreased response to paired AFC. c Most common acyl chain distribution across FFA and phospholipid class. Each coloured bar represents the summed abundance of all lipids containing a given acyl chain as a percentage of the summed abundance of all acyls for each lipid class. d Response of phospholipids containing the most common acyl chains. Each pixel in the heatmap represents the AFC-induced change in summed abundance of those species in each class containing a given acyl chain. Dotted boxes indicate brain regions where AFC induces a decrease in myristoyl containing phospholipids that could potentially represent substrates for phospholipase A mediated release of myristic acid. CeA—central amygdala, BLA— basolateral amygdala, PFC—prefrontal cortex, VH—ventral hippocampus, DH—dorsal hippocampus, CB—cerebellum, PA—phosphatidic acid, PC—phosphatidylcholine, PE—phosphatidylethanolamine, PG—phosphatidylglycerol, PS—phosphatidylserine. Source data are provided as a Source Data file.
