Fig. 3: Comparison of camptothecin and vinblastine/vincristine biosynthesis pathways.

a Chemical representation of the iridoid pathway in C. roseus and C. acuminata. Different modifications resulting from reaction steps in the two species are indicated in blue. The camptothecin biosynthesis pathway in C. acuminata is outlined by the red-dotted box. b UPLC traces illustrate representative compound peaks for the target products of CaLAMT and CrLAMT.