Table 2 CpGs significantly associated with lipids levels in more than one racial/ethnic group.

From: A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids

CpG

RACE

BETA

SE

P

MAPINFO

GENE

GROUP

CpG Island

Enhancer

DHS

HDL

cg17901584*

EA

0.032

0.005

1.68 × 10−53

1:55353706

DHCR24

TSS1500

S_Shore

  
 

AA

0.036

0.003

3.05 × 10−24

      

cg24002003

EA

0.010

0.002

2.39 × 10−09

15:101668143

   

Y

Y

 

AA

0.013

0.002

7.32 × 10−09

      

cg02650017*

EA

0.006

0.001

2.82 × 10−12

17:47301614

PHOSPHO1

Body

Island

Y

 
 

AA

0.005

0.001

9.70 × 10−09

      

cg06500161*

EA

−0.021

0.003

6.32 × 10−41

21:43656587

ABCG1

Body

S_Shore

Y

 
 

AA

−0.017

0.002

1.45 × 10−11

      

LDL

cg22930808

EA

0.0001

0.00002

4.38 × 10−08

3:122281881

PARP9

5’UTR

N_Shore

  
 

AA

0.0002

0.00003

1.18 × 10−09

      

TG

cg03725309

EA

−0.007

0.0011

6.29 × 10−24

1:109757585

SARS

Body

S_Shore

 

Y

 

AA

−0.008

0.001

2.21 × 10−11

      

cg16246545

EA

−0.011

0.002

1.33 × 10−24

1:120255941

PHGDH

Body

S_Shore

  
 

AA

−0.012

0.0019

1.48 × 10−08

      

cg14476101*

EA

−0.018

0.003

2.88 × 10−39

1:120255992

PHGDH

Body

S_Shore

  
 

AA

−0.020

0.0024

7.53 × 10−15

      

cg19693031*

EA

−0.019

0.0021

9.14 × 10−57

1:145441552

TXNIP

3’UTR

   
 

AA

−0.034

0.0034

1.31 × 10−62

      
 

HA

−0.028

0.0132

5.76 × 10−9

      

cg19266329

EA

−0.006

0.0008

2.62 × 10−13

1:145456128

   

Y

 
 

AA

−0.009

0.0013

1.17 × 10−11

      

cg19213703

EA

−0.005

0.0012

9.42 × 10−08

3:177554561

   

Y

 
 

AA

−0.008

0.0019

4.39 × 10−09

      

cg06690548*

EA

−0.012

0.0024

2.92 × 10−37

4:139162808

SLC7A11

Body

   
 

AA

−0.011

0.0011

2.71 × 10−21

      

cg26403843

EA

0.011

0.002

2.21 × 10−18

5:158634085

RNF145

Body

N_Shelf

  
 

AA

0.017

0.0022

5.12 × 10−13

      

cg03717755*

EA

0.009

0.001

1.56 × 10−18

6:16136539

MYLIP

Body

 

Y

 
 

AA

0.011

0.0017

4.87 × 10−15

      

cg18336453

EA

−0.004

0.0008

2.31 × 10−10

6:43082296

PTK7

Body

 

Y

 
 

AA

−0.007

0.0011

8.87 × 10−10

      

cg07504977*

EA

0.012

0.0016

8.24 × 10−32

10:102131012

  

N_Shelf

Y

 
 

AA

0.015

0.002

2.47 × 10−12

      

cg11376147*

EA

−0.004

0.0006

3.54 × 10−18

11:57261198

SLC43A1

Body

 

Y

Y

 

AA

−0.006

0.001

1.32 × 10−14

      

cg00574958*

EA

−0.009

0.0012

1.50 × 10−115

11:68607622

CPT1A

5’UTR

N_Shore

  
 

AA

−0.011

0.0011

2.34 × 10−50

      
 

HA

−0.013

0.0025

2.65 × 10−14

      

cg09737197*

EA

−0.008

0.0013

1.86 × 10−32

11:68607675

CPT1A

5’UTR

N_Shore

  
 

AA

−0.011

0.002

1.38 × 10−15

      

cg17058475*

EA

−0.010

0.0013

4.29 × 10−65

11:68607737

CPT1A

5’UTR

N_Shore

  
 

AA

−0.011

0.0025

8.52 × 10−28

      

cg10919522

EA

−0.005

0.001

5.59 × 10−08

14:74227441

C14orf43

5’UTR

S_Shore

Y

 
 

AA

−0.010

0.0014

1.02 × 10−10

      

cg15863539*

EA

0.003

0.0009

8.83 × 10−17

17:17716950

SREBF1

Body

S_Shore

  
 

AA

0.004

0.0006

1.93 × 10−09

      

cg20544516*

EA

0.006

0.0006

3.71 × 10−25

17:17717183

MIR33B;SREBF1

Body;Body

S_Shore

  
 

AA

0.007

0.0008

3.18 × 10−14

      

cg11024682*

EA

0.010

0.0013

1.08 × 10−50

17:17730094

SREBF1

Body

S_Shelf

  
 

AA

0.016

0.0013

5.77 × 10−28

      
 

HA

0.019

0.0033

1.59 × 10−8

      

cg08857797*

EA

0.006

0.001

1.93 × 10−12

17:40927699

VPS25

Body

   
 

AA

0.008

0.0017

1.73 × 10−10

      

cg22304262

EA

−0.006

0.0012

6.04 × 10−12

19:47287778

SLC1A5

Body;5’UTR

N_Shelf

  
 

AA

−0.008

0.0012

3.31 × 10−08

      

cg08309687

EA

−0.009

0.0017

4.49 × 10−14

21:35320596

   

Y

Y

 

AA

−0.014

0.0024

3.00 × 10−11

      

cg0188189*

EA

0.005

0.0008

6.07 × 10−21

21:43652704

ABCG1

Body

N_Shelf

  
 

AA

0.007

0.0011

1.21 × 10−17

      

cg02370100*

EA

0.005

0.0008

1.45 × 10−13

21:43655256

ABCG1

Body

Island

  
 

AA

0.006

0.0014

1.49 × 10−08

      

cg07397296

EA

0.007

0.0012

4.68 × 10−16

21:43655316

ABCG1

Body

Island

 

Y

 

AA

0.007

0.0012

3.98 × 10−08

      

cg06500161*

EA

0.016

0.0015

4.73 × 10−111

21:43656587

ABCG1

Body

S_Shore

Y

 
 

AA

0.017

0.0023

2.72 × 10−39

      
 

HA

0.021

0.0033

7.68 × 10−10

      
  1. *Identified in previous epigenome-wide association of lipids; SD Standard error, CHR Chromosome, DHS DNase I hypersensitive site, HDL high-density lipoprotein, LDL low-density lipoprotein, TG triglycerides, EA European ancestry, AA African ancestry, HA Hispanic ancestry, NEA = 11,114, NAA = 4,452, NHA = 699; The statistic is a likelihood ratio test (LRT) which asymptotically follows an equal mixture of 1 degree of freedom (df) χ2 distribution and 2 df χ2 distribution; CI can be calculated as (BETA-1.96*SE, BETA + 1.96*SE). A p-value was considered significant in a specific racial/ethnic group if it was <1.09 × 10−7 (Bonferroni correction for the number of CpG probes tested).
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