Fig. 4: Increased proliferation of dopaminergic cells in MPS-IIIA mice begins during embryonic life. | Nature Communications

Fig. 4: Increased proliferation of dopaminergic cells in MPS-IIIA mice begins during embryonic life.

From: Altered heparan sulfate metabolism during development triggers dopamine-dependent autistic-behaviours in models of lysosomal storage disorders

Fig. 4

a, aʹ Immunohistochemical analysis of TH+ cells in the substantia nigra/ventral tegmental area (SN/VTA) complex revealed that MPS-IIIA mice had increased number of TH + cells (scale bar: 100 µm) and increased dendritic arbours density in substantia nigra (SN) (scale bar: 25 µm). b An increased number of TH+ neurons is observed in embryonic, newborn and juvenile MPS-IIIA mice (scale bar: 100 µm). c, d MPS-IIIA mice have an increased number of BrdU+ cells in the mesencephalon (scale bar: 20 µm), and e increased number of LMX1A+ cells (scale bar: 50 µm). Histograms represent mean ± S.E.M. *p < 0.05, **p < 0.01 vs WT, between groups.

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