Fig. 5: Time-dependent increased proliferation of dopaminergic cells in MPS-IIIA mesencephalic neurons. | Nature Communications

Fig. 5: Time-dependent increased proliferation of dopaminergic cells in MPS-IIIA mesencephalic neurons.

From: Altered heparan sulfate metabolism during development triggers dopamine-dependent autistic-behaviours in models of lysosomal storage disorders

Fig. 5

a, b Primary cultures of mesencephalic neurons reproduce the progression of the TH phenotype in vitro, showing an increase in dopaminergic cell density at DIV4. However, at DIV14, while in WT cells there was a time-dependent increase, MPS-IIIA cells showed a decrease of TH+ cells density (scale bar: 75 µm). c MAP2 + neurons were not changed at DIV4 and DIV7, while were reduced at DIV14 in MPS-IIIA cells. Histograms represent mean ± S.E.M. *p < 0.05 vs WT, between groups; #p < 0.05 vs WT, within groups; °p < 0.05 vs MPS-IIIA, within groups.

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