Fig. 8: Autistic-like behaviours and increased DA cell number are also present in an MPS-II mouse model. | Nature Communications

Fig. 8: Autistic-like behaviours and increased DA cell number are also present in an MPS-II mouse model.

From: Altered heparan sulfate metabolism during development triggers dopamine-dependent autistic-behaviours in models of lysosomal storage disorders

Fig. 8

a, aʹ No locomotion differences were present in the 1-month-old MPS-II mice, compared to WT littermates. Walking pattern track plots are shown. b, bʹ MPS-II mice manifested stereotypies. c-cʹ They did not show an increased percentage of retreats in the social tube test, but presented increased sociability index. d, e No significant differences were found in the hanging wire and in the fear conditioning test between WT and MPS-II mice. f MPS-II mice, compared to WT littermates, had increased expression of TH in the striatum and g, gʹ showed increased number of TH+ cells in the SN/VTA complex. A representative WB for each condition is presented (scale bar: 100 µm). Histograms represent mean ± S.E.M. *p < 0.05 vs WT, between groups.

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