Fig. 3: LINC00842 promotes anabolic metabolism in PDAC cells. | Nature Communications

Fig. 3: LINC00842 promotes anabolic metabolism in PDAC cells.

From: LINC00842 inactivates transcription co-regulator PGC-1α to promote pancreatic cancer malignancy through metabolic remodelling

Fig. 3

a–d LINC00842 expression change significantly altered the abundance of tricarboxylic acid cycle (TCA) intermediates (a and c) or long-chain acylcarnitines (b and d). e–h LINC00842 overexpression (OE) or knockdown (KD) significantly changed the levels of TCA intermediates expressed as mass isotopomer percentage. i–l LINC00842 expression change significantly altered the levels of palmitate (C16:0, i and k) and stearate (C18:0, j and l) paired mass isotopomer percentages. Results in (a–l) are mean ± SD from 3 independent experiments. *P < 0.05; **P < 0.01, and ***P < 0.001 were determined by Student’s t-test (two-tailed).

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