Table 1 Corresponding relationship between new annotation classification and TBS classification.

From: Hybrid AI-assistive diagnostic model permits rapid TBS classification of cervical liquid-based thin-layer cell smears

New annotation classification

Corresponding TBS classification

Category

Definition

AGC_A (C1)

AGC_NOS, AGC_FN, AIS, ADC

Glandular intraepithelial lesions

Atypical glandular cells, pathological morphology similar to cervical gland cells

AGC_B (C2)

AGC_NOS, AGC_FN, AIS, ADC

Glandular intraepithelial lesions

Atypical glandular cells, other pathological morphology

ASC_L_S (C3)

ASCUS, LSIL, ASCH, HSIL, SCC

Squamous intraepithelial lesion

Single atypical squamous cell with low nuclear/cytoplasmic ratio (excluding Koilocytes)

KC (C4)

LSIL

Squamous intraepithelial lesion

Single koilocyte

ASC_L_F (C5)

ASCUS, LSIL, ASCH, HSIL, SCC

Squamous intraepithelial lesion

Atypical squamous cells with low nuclear/cytoplasmic ratio, arranged in sheets or clusters

ASC_H_B (C6)

ASCUS, ASCH, HSIL, SCC

Squamous intraepithelial lesion

Atypical squamous cells with high nuclear/cytoplasmic ratio, arranged in clusters (cells number ≥ 10)

ASC_H_M (C7)

ASCUS, ASCH, HSIL, SCC

Squamous intraepithelial lesion

Atypical squamous cells with high nuclear/cytoplasmic ratio, arranged in clusters (2 ≤ cells number ≤ 10)

ASC_H_S (C8)

ASCUS, ASCH, HSIL, SCC

Squamous intraepithelial lesion

Single atypical squamous cell with high nuclear/cytoplasmic ratio

SCC_R (C9)

SCC

Squamous intraepithelial lesion

Keratinizing squamous cell carcinoma cells

SCC_G (C10)

SCC

Squamous intraepithelial lesion

Non-Keratinizing squamous carcinoma cells

MC (C11)

NIL

Normal

Superficial squamous epithelium

SC (C12)

NIL

Normal

Single normal cell with high nuclear/cytoplasmic ratio (Including parabasal cells, lymphocyte cells, and reserve cells etc.)

RC (C13)

NIL

Normal

Repair and metaplasia cells

GEC (C14)

NIL

Normal

Glandular epithelial cells of cervical tube

EMC (C15)

EMC

EMC

Endometrial cells

TRI (C16)

TRI

Infectious lesion

Trichomonas vaginalis

CAN (C17)

CAN

Infectious lesion

Candida albicans

HSV (C18)

HSV

Infectious lesion

Herpes simplex virus

ACTINO (C19)

ACTINO

Infectious lesion

Actinomycetes

CC (C20)

CC

Infectious lesion

Clue cells

PH (C21)

NIL

Evidence of infectious lesion

Perinuclear halo

Neutrophils (C22)

NIL

Normal

Neutrophils

Mucus (C23)

NIL

Normal

Mucus

Debris (C24)

NIL

Normal

Debris