Fig. 2: Construction of an atlas of regulatory sites in gliomas. | Nature Communications

Fig. 2: Construction of an atlas of regulatory sites in gliomas.

From: Mapping chromatin accessibility and active regulatory elements reveals pathological mechanisms in human gliomas

Fig. 2

A Numbers of samples from gliomas of different grades for which ATAC-seq, ChIP-seq, and RNA-seq data were collected. B Representative peaks of ATAC-seq, ChIP-seq, RNA-seq at the NRXN2 gene in pilocytic astocytomas (PA04) and glioblastoma (GB01) samples. Note high expression of the NRXN2 in PA in comparison to GB, which correlates with the lack of the ATAC-seq signal in GB (shadowed blocks). C Total numbers of peaks identified in all samples across performed experiments. D Numbers of identified common and variable active regulatory elements, genes and transcripts. E Example of promoter-enhancer interactions identified using Hi-C data (Won et al., 2016). Brown dots represent “anchors”, while brown horizontal lines depict predicted interaction sites.

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