Fig. 8: Postnatal onset of Tsc1 haploinsufficiency in PV cells induces premature putative synapse formation. | Nature Communications

Fig. 8: Postnatal onset of Tsc1 haploinsufficiency in PV cells induces premature putative synapse formation.

From: Sensitive period for rescuing parvalbumin interneurons connectivity and social behavior deficits caused by TSC1 loss

Fig. 8

a–f Representative immunostained sections of somatosensory cortex labeled for PV/GFP (blue/green) and gephyrin (red) in P22 PV-Cre;RCE;Tsc1+/+ (a–c) and PV-Cre;RCE;Tsc1flox/+ mice (d–f). White arrowheads indicate PV/Gephyrin colocalized puncta (c and f). Scale bar: 5 μm. g Quantification of PV/GFP-Gephyrin colocalized puncta (Welch’s t-test, *p = 0.0121). Number of mice: n = 5 for PV-Cre;RCE;Tsc1+/+ and n = 7 for PV-Cre;RCE;Tsc1flox/+. Data represent mean ± SEM. Source data are provided as a Source Data file.

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