Fig. 8: Model of the translation-independent function of nex-mRNA.
From: Extracellular mRNA transported to the nucleus exerts translation-independent function
The tumor-associated nex-IL1β-mRNA 3′-UTR was trapped by ZC3H12D protein on the NK cell surface and introduced to the nucleus via its C-terminal containing a proline-rich domain. Then, this may regulate antiapoptotic gene expression associated with RNA Pol II and control NK cell migration, survival, and sustainability of IFN-γ production.
