Fig. 1: The FOXG1 syndrome Heterozygous model mouse displays ASD-like social behavioral impairments. | Nature Communications

Fig. 1: The FOXG1 syndrome Heterozygous model mouse displays ASD-like social behavioral impairments.

From: FoxG1 regulates the formation of cortical GABAergic circuit during an early postnatal critical period resulting in autism spectrum disorder-like phenotypes

Fig. 1

a–c Representative traces of animal location of wild type and FoxG1 Heterozygous (LacZ knock-in) littermates are shown for each 10 min of the Habituation, Sociability, and Social Novelty sessions (a). Social behavior of the animals was analyzed by comparing the time spent in each chamber of the three-chamber assay (b). Social behavior scores of the animals are calculated based on the time spent at the social side (orange bars in b) of the chambers (c, p = 0.00753**). Wild type animals preferred to spend time in the social side of the chambers (b, orange bar graphs) while Heterozygous animals did not exhibit a social preference (b, purple * and NS for left vs. right chamber bar graphs). WT: n = 26, p = 0.261(Hab), p = 2.55 × 10−7****(Soc), p = 4.90 × 10−5**** (Nov), Het: n = 26, p = 0.911(Hab), p = 0.0117*(Soc), p = 0.262(Nov). In addition, Heterozygous animals preferred the middle chamber (filled purple bar graph, p = 0.00759**) in the third social novelty session and avoided the two lateral chambers harboring other mice. d–f Other behavioral paradigms tested: Heterozygous animals showed normal locomotion (d, n = 14 each), mildly decreased anxiety (e, n = 14 each, p = 0.0334*) and reduced working memory (f, n = 28 each, p = 0.000180***). Data are mean ± SEM, p values are from two-tailed t-test.

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