Fig. 4: Resolution of ester and methane derivatives bearing quaternary stereocenters. | Nature Communications

Fig. 4: Resolution of ester and methane derivatives bearing quaternary stereocenters.

From: Access to enantioenriched compounds bearing challenging tetrasubstituted stereocenters via kinetic resolution of auxiliary adjacent alcohols

Fig. 4

a Scope of esters with α-quaternary stereocenters. Variation of the standard conditions: 5f: 10 °C, 28 h; 5b/5j/5m: 20 °C; 5c/5d: (S)-BTM (10 mol%); 5g/5i/5l/5n/5o: (S)-BTM (10 mol%), −10 °C. b Scope of tetrasubstituted methane derivatives. Variations of the standard conditions: 7c/7g: −10 °C, 23 h; 7h: (S)-BTM (15 mol%), −20 °C, 40 h; 7i: (S)-BTM (4 mol%), iPr2NEt (1.0 equiv), toluene; 7j: iPr2NEt (1.0 equiv), toluene, 12 h; 7k/7m: (S)-BTM (5 mol%). c conversion.

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