Table 4 Subgroup analysis: the effects of the presence of a side branch, aneurysm size, aspect ratio and hypertension on flow diversion efficacy (determined by AMVR).

From: In-silico trial of intracranial flow diverters replicates and expands insights from conventional clinical trials

 

Normotensive

Hypertensive

 

SO/subtotal

Difference (95% CI)

p value

SO/subtotal

Difference (95% CI)

p value

Side branch

      

Yes

70.6% (24/34)

21.1% (4.2 to 38.6%)

0.013

52.9% (18/34)

24.2% (3.4 to 43.0%)

0.023

No

91.7% (44/48)

Ref

Ref

77.1% (37/48)

Ref

Ref

Size

      

>10 mm

73.1% (19/26)

14.4% (−2.8 to 34.6%)

0.108

50.0% (13/26)

25.0% (3.0 to 45.3%)

0.026

<10 mm

87.5% (49/56)

Ref

Ref

75.0% (42/56)

Ref

Ref

Aspect ratio

      

>1.6

77.8% (14/18)

6.7% (−10.5 to 30.6%)

0.514

55.6% (10/18)

14.7% (−8.5 to 38.7%)

0.242

<1.6

84.4% (54/64)

Ref

Ref

70.3% (45/64)

Ref

Ref

Hypertension

82.9% (68/82)

Ref

Ref

67.1% (55/82)

15.8% (2.6 to 28.4%)

0.0196

  1. p values were computed using the χ2 test.
  2. AMVR aneurysm mean (time-averaged) velocity reduction, SO successful occlusion indicated by AMVR, Ref group taken as reference.
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