Fig. 2: High expression of TAM markers in HCC tumors suggests poor prognosis. | Nature Communications

Fig. 2: High expression of TAM markers in HCC tumors suggests poor prognosis.

From: Single-cell RNA sequencing shows the immunosuppressive landscape and tumor heterogeneity of HBV-associated hepatocellular carcinoma

Fig. 2

a TAMs had enriched expression for multiple immunosuppressive markers. b TAM cell clusters expressing cancer-promoting M2 macrophage marker CD163 had concurrent enrichment for LAIR1 expression. c Expressions of CD163 and LAIR1 were significantly correlated in both in-house and TCGA datasets. Student’s t test (two-sided). d High expressions of LAIR1 and HAVCR2 were significant associated with poorer disease-free and overall survivals, respectively. Log-rank test (two-sided). e Overlap of the LAIR1 and M2 macrophages (CD163) using multicolor immunofluorescence staining in Case #713. Scale bar = 50 µm. More than ten fields each under ×40 and ×100 magnification were examined. Source data are provided as a Source Data file.

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