Fig. 7: SNPs in APCS predispose stem-cell transplant recipients to IPA.
From: Serum amyloid P component is an essential element of resistance against Aspergillus fumigatus
a, b Cumulative incidences of IPA according to APCS genotypes (IFIGEN cohort) are shown. a Cumulative incidence according to donor or recipient rs2808661 genotypes: donor GG (22.8%, n = 348, reference), GA (21.4%, n = 127; P = 0.67) and AA (55.6%, n = 8; P = 0.04), and recipient GG (20.3%, n = 352, reference), GA (25.0%, n = 119; P = 0.58) and AA (36.4%, n = 12; P = 0.08). b Cumulative incidence according to donor or recipient rs3753869 genotypes: donor CC (20.6%, n = 327, reference), CA (25.9%, n = 136; P = 0.30) and AA (42.9%, n = 20; P = 0.03), and recipient CC (23.4%, n = 285, reference), CA (20.4%, n = 183; P = 0.59) and AA (18.2%, n = 15; P = 0.41). Data were censored at 24 months, and relapse and death were competing events. a, b P-values are for Gray’s test (two-sided). c Levels of SAP in sera (left) and BALFs (right) of hematological patients from the FUNBIOMICS cohort. Sera, controls, n = 14; IPA, n = 20. BALFs, n = 7; IPA, n = 9. Mean ± SEM. ***P = 0.0007 (two-sided, Mann–Whitney U-test). d, e Levels of SAP in serum of IPA patients with donor rs2808661 (d) and donor rs3753869 (e). Donor rs2808661, GG (n = 12), GA (n = 3), AA (n = 4) (d) and Donor rs3753869, CC (n = 13), CA (n = 3), AA (n = 4) (e) analyzed separately for the different genotype (d, e, left) or AA vs. GG + GA (d, right) and AA vs. CC + CA (e, right). AA vs. GA, ***P = 0.0006 (two-sided, unpaired t-test); AA vs. GG + GA, *P = 0.05 (two-sided, Mann–Whitney U-test); AA vs. CC, *P = 0.03 (two-sided, unpaired t-test); AA vs. CC + CA, *P = 0.02 (two-sided, unpaired t-test). c–e, Mean ± SEM.
