Fig. 2: Reaction optimization.
From: Ni-catalyzed hydroaminoalkylation of alkynes with amines
Reaction conditions: 1a (0.20 mmol), 2a (0.22 mmol), toluene (2.0 mL) under N2 for 1 h; yield was determined by 1H NMR using Cl2CHCHCl2 as the internal standard. IPrMe = 1,3-bis(2,6-diisopropylphenyl)-4,5-dimethyl-2,3-dihydro-1H-imidazole. SIPr = 1,3-bis(2,6- diisopropylphenyl)imidazolidine. IMes = 1,3-dimesityl-2,3-dihydro-1H-imidazole. dppe = 1,2-bis(diphenylphosphino)ethane.
