Fig. 8: FYN-TRAF3IP2-driven NF-κB activation sensitizes lymphoma cells to inhibition of BCL-XL/BCL2. | Nature Communications

Fig. 8: FYN-TRAF3IP2-driven NF-κB activation sensitizes lymphoma cells to inhibition of BCL-XL/BCL2.

From: Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified

Fig. 8

a Heatmap representation of relative transcript abundance of pro-survival and pro-apoptosis factors in naive CD4+ T cells, CD4+GFP− stromal T cells and FYN-TRAF3IP2-expressing lymphoma cells. The color scale represents the distribution for each row as mean ± SD. b Immunofluorescence images for BCL-XL and GFP in FYN-TRAF3IP2-driven murine lymphomas (right, n = 5 mice) and quantification of BCL-XL signal intensity in the lymphoma stromal cells (n = 4184 cells) and GFP+ malignant cells (n = 510 cells). Scalebars represent 20 µm. Dashed lines represent the median and dotted lines represent the lower and upper quartile in the violin plots. p values were calculated with a two-sided Mann−Whitney test. c High (left) and low (right) magnification images of immunohistochemistry staining for BCL-XL on case PTCL2. Scalebars represent 50 µm (left) and 200 µm (right). d Growth inhibition of sorted FYN-TRAF3IP2-expressing lymphoma cells and sorted CD4+ T cells after a 48-h treatment with ABT-263. n = 3 replicates per condition. Data are represented as mean ± SD.

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