Fig. 2: Cryo-EM structure of C9orf72:ARF1-SMCR8:WDR41 complex.
From: Structural basis for the ARF GAP activity and specificity of the C9orf72 complex
a Cryo-EM densities and the refined atomic model of the complex. The domain colored as followed: SMCR8longin, cornflower blue; SMCR8DENN, gray; C9orf72longin, olive; C9orf72DENN, goldenrod; WDR41, medium purple; ARF1: orange. b ARF1 sits on the top of the two longin domains. The switch I and II of ARF1 are colored in yellow and tan, respectively. c Structural comparison of ARF1 in GTP versus GDP-bound states (from the left to right panels, switch I and II and interswitch). ARF1 in GTP state fits into the density.
