Fig. 4: Potential ligand–receptor interactions analyses in fibroblast subpopulations. | Nature Communications

Fig. 4: Potential ligand–receptor interactions analyses in fibroblast subpopulations.

From: Single-cell RNA-seq reveals fibroblast heterogeneity and increased mesenchymal fibroblasts in human fibrotic skin diseases

Fig. 4

a, b Heatmap showing the numbers of inter-populations communications with each other in normal scars (a) and in keloid tissues (b). c The ligand–receptor pairs exhibit significant changes in specificity between any one of the population and any one type of fibroblast in normal scars versus keloid. The left panel shows that one type of fibroblast expresses receptors and receives ligand signals from other populations. The right panel shows that one other population expresses receptors and receives ligand signals from one type of fibroblast. d, e Putative TGFβ and POSTN relative signaling within fibroblasts and other cell populations in normal scars (d) and in keloid tissues (e). All arrows are pointing to the receptors. Average expression levels for each ligand/receptor are presented as a heatmap plot. Black indicates maximum relative expression and white indicates low or no expression of a particular gene.

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