Fig. 4: Decagram scale synthesis and comparison of Co-catalyzed versus Cu-based allylic C–H functionalizations.

a Decagram scale synthesis of 2 and 63. b Comparison of the reaction patterns of Co- versus Cu-catalyzed cyclization of sterically hindered alkenes. c, d Comparison of selectivities of Co-catalyzed versus Mn/Cu-mediated allylic C–H alkylation of di- and trisubstituted alkenes.