Fig. 8: ZsGreen-positive and -negative mTEC from Eedfl/fl::ZsGreen::β5tCre mice are transcriptomically distinct from mTEC isolated from Eedfl/fl mice. | Nature Communications

Fig. 8: ZsGreen-positive and -negative mTEC from Eedfl/fl::ZsGreen::β5tCre mice are transcriptomically distinct from mTEC isolated from Eedfl/fl mice.

From: Indispensable epigenetic control of thymic epithelial cell development and function by polycomb repressive complex 2

Fig. 8

a Principal component analysis of bulk RNA-seq samples. b Scatter plots of differentially expressed genes for each type of mTEC showing genes belonging to gene ontology terms related to antigen presentation and processing (GO:0019882 - green), proteasome (KEGG:03050 - yellow) and immunoproteasome (CORUM:39 - orange). CPM = counts per million. Dashed lines indicate a fold change of 1 and arrows indicate the direction of higher expression. Filled points are significant at FDR < 0.05. c A dot plot showing significantly enriched biological pathways within genes significantly upregulated in each type of mTEC.

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