Fig. 1: Clock gene expression is altered in primary NB tumor samples and correlates with poor clinical outcomes.
From: Restoration of the molecular clock is tumor suppressive in neuroblastoma
Kaplan-Meier analysis of overall survival (OS) in patient cohort 1 (Kocak n = 476, GEO: GSE45547). Graphs depict p-values corrected for multiple testing (Bonferroni correction) of cutoff levels for RORα, BMAL1, and REV-ERBα. Correlations between clock gene expression, INSS stages, and MYCN amplification status are shown. MNA = MYCN-amplified; S1–4S = stage1-4S; 476 of the 649 samples were annotated with survival data. The box plot is defined by two lines at the 25th and 75th percentile. A line is drawn inside the box at the 50th percentile.
