Fig. 2: The footprint of ORC–Cdc6 on the ARS1 origin DNA. | Nature Communications

Fig. 2: The footprint of ORC–Cdc6 on the ARS1 origin DNA.

From: The structure of ORC–Cdc6 on an origin DNA reveals the mechanism of ORC activation by the replication initiator Cdc6

Fig. 2

a The DNA-binding modules in each subunit are labeled around the DNA sequence: the initiator-specific motif (ISM) of the AAA+ domains, the β-hairpin or/and HTH-motif of the WHD domain, and the basic residue patch (BP). Nucleotides in red are the extended footprint in ORC–Cdc6 relative to ORC alone. b Structure of the DNA-binding modules around the ACS element. c Structures of DNA-binding modules around the B1 element of the origin DNA.

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