Fig. 1: Somatosensory suppression of neurons in primary auditory cortex (A1) of awake, head-fixed mice.
From: Subcortical circuits mediate communication between primary sensory cortical areas in mice
a Top: Schematic of recording setup. MGB, medial geniculate body. Bottom: Example frequency response profiles and PSTHs of best frequency (BF) responses from a unit recorded in A1 of an awake, passively listening mouse, illustrating tone responses (80 dB SPL) with (orange) or without (black) concurrent whisker stimulation. sp/s, spikes per second. Median frequency response profiles for tones presented at 60 (b) and 80 dB SPL (c) across units recorded in A1 of awake mice (60 dB SPL change in BF response: P = 1.7 × 10−12, n = 140, two-sided Wilcoxon signed-rank test; 80 dB SPL change in BF response: P = 1.2 × 10−13, n = 140, two-sided Wilcoxon signed-rank test). Relationship between normalized firing rate (FR) for all A1 units (black dots) for tones presented at 60 (d) or 80 dB SPL (e) across all frequencies either with (“combined”) or without (“tones alone”) whisker stimulation. Thick multi-colored lines show the running median of this relationship (window: 0.1 normalized firing rate), and the colors denote the distance from BF. The diagonal dashed red line is the line of equality. A larger distance between the multi-colored line and the diagonal line at the blue end than at the red end indicates divisive scaling. The shaded area indicates the 95% confidence intervals of the means (a frequency response profiles), the s.e.m. (a PSTHs) or the 95% nonparametric confidence intervals of the median (b, c). n = 140 (4 mice).
