Fig. 4: Mild cognitive impairment (MCI) conversion in the ADNI and an Atlanta-based MCI cohorts.
From: Higher CSF sTNFR1-related proteins associate with better prognosis in very early Alzheimer’s disease
Conversion to dementia diagnosis based on the same p-Tau181 levels and a regression-based prediction of sTNFR1 score (ysTNFR1) reproduced the prognostic profiles from ADNI (a) in the replication cohort (b n = 49). *Lower conversion compared to those with p-Tau181 ≥ 24.1 pg/mL but low ysTNFR1 (p = 0.049 in ADNI and p = 0.038 in the Atlanta cohort). †Two subgroups with p- Tau181 < 24.1 were combined due to small numbers, p = 0.068 vs. high p-Tau181 and low ysTNFR1. Source data are provided as a Source Data file.
