Table 1 Subjects included in study from ADNI, with p values shown for all continuous factors without log10 transformation but also for CSF inflammatory proteins after log10 transformation.
From: Higher CSF sTNFR1-related proteins associate with better prognosis in very early Alzheimer’s disease
NC (n = 111) | MCI (n = 174) | AD (n = 97) | P | p for log10 values | |
|---|---|---|---|---|---|
Male (%) | 57 (51%) | 112 (64%) | 56 (58%) | 0.090 | |
Age, mean (SD) | 75.8 (5.3) | 75.2 (7.6) | 75.1 (7.8) | 0.659 | |
Education, mean (SD) | 15.7 (2.9) | 15.8 (2.9) | 15.2 (3.0) | 0.246 | |
Race | 0.001 | ||||
Asian (%) | 0 | 5 (3%) | 0 | ||
Black/African American (%) | 9 (8%) | 3 (2%) | 0 | ||
White (%) | 102 (92%) | 166 (95%) | 97 (100%) | ||
Non-Hispanic (%) | 109 (98%) | 170 (98%) | 96 (99%) | 0.595 | |
BMI (kg/m2) | 26.9 (4.4) | 25.9 (3.9) | 25.4 (3.6) | 0.017 | |
SBP (mmHg) | 133.8 (16.0) | 132.3 (15.5) | 134.1 (17.0) | 0.626 | |
Having at least one APOE ε4 allele (%) | 26 (23%) | 95 (55%) | 65 (67%) | <0.001 | |
CDR-SB (SD) | 0.05 (0.24) | 1.69 (1.00) | 4.48 (1.88) | <0.001 | |
CSF biomarkers | |||||
Aβ42, mean (SD) in pg/mL | 209.8 (52.7) | 165.6 (52.4) | 142.5 (36.7) | <0.001 | |
t-Tau, mean (SD) in pg/mL | 69.3 (30.2) | 105.2 (61.3) | 121.8 (57.7) | <0.001 | |
p-Tau181, mean (SD) in pg/mL | 27.0 (17.2) | 37.0 (21.3) | 43.2 (19.8) | <0.001 | |
t-Tau/Aβ42 ≥ 0.39 (%) | 32 (29%) | 120 (69%) | 85 (88%) | <0.001 | |
WU-sTREM2, mean (SD) in pg/mL | 2427 (774) | 2366 (726) | 2474 (802) | 0.611 | – |
MSD-sTREM2, mean (SD) in pg/mL | 4692 (2274) | 4529 (2539) | 4347 (1975) | 0.628 | 0.871 |
MSD-GRN, mean (SD) in pg/mL | 1598 (565) | 1612 (798) | 1626 (425) | 0.963 | 0.808 |
TNF-α, mean (SD) in pg/mL | 1.91 (1.44) | 1.83 (1.20) | 1.73 (0.46) | 0.522 | 0.837 |
sTNFR1, mean (SD) in pg/mL | 870 (227) | 904 (237) | 874 (249) | 0.434 | 0.353 |
sTNFR2, mean (SD) in pg/mL | 1060 (512) | 1093 (319) | 1048 (284) | 0.597 | 0.299 |
TGFβ1, mean (SD) in pg/mL | 109 (42) | 108 (42) | 107 (37) | 0.951 | 0.987 |
TGFβ2, mean (SD) in pg/mL | 159 (39) | 161 (53) | 159 (47) | 0.398 | 0.168 |
TGFβ3, mean (SD) in pg/mL | 9.2 (23.3) | 11.1 (28.3) | 14.2 (31.1) | 0.438 | 0.675 |
IP-10, mean (SD) in ng/mLa | 5.47 (1.78) | 5.08 (2.06) | 5.01 (1.95) | 0.253 | 0.117 |
IL-6, mean (SD) in pg/mL | 4.78 (3.33) | 5.27 (5.78) | 5.03 (4.74) | 0.676 | 0.970 |
IL-7, mean (SD) in pg/mL | 1.49 (2.75) | 1.16 (0.79) | 1.41 (1.26) | 0.238 | 0.338 |
IL-9, mean (SD) in pg/mL | 3.70 (1.91) | 3.33 (1.46) | 3.45 (1.65) | 0.239 | 0.416 |
IL-10, mean (SD) in pg/mL | 5.80 (2.74) | 7.97 (28.55) | 5.57 (2.60) | 0.532 | 0.431 |
IL-12p40, mean (SD) in pg/mL | 1.11 (1.03) | 5.81 (48.01) | 1.17 (1.03) | 0.470 | 0.159 |
IL-21, mean (SD) in pg/mL | 12.93 (14.71) | 11.78 (12.10) | 12.10 (12.46) | 0.766 | 0.820 |
sICAM-1, mean (SD) in pg/mL | 355.4 (184.1) | 400.2 (215.6) | 368.7 (187.3) | 0.154 | 0.100 |
sVCAM-1, mean (SD) in ng/mLa | 41.3 (21.0) | 44.7 (26.1) | 48.7 (67.4) | 0.413 | 0.468 |
