Fig. 1: An overview of the study showing the discovery of panels of stool proteins arising from an initial aptamer-based screen. | Nature Communications

Fig. 1: An overview of the study showing the discovery of panels of stool proteins arising from an initial aptamer-based screen.

From: Predicting disease course in ulcerative colitis using stool proteins identified through an aptamer-based screen

Fig. 1

This consort diagram shows how the initial screen consisting of 1129 proteins were narrowed down to 19 stool proteins during validation. Various prediction models identified 7 stool proteins that could track clinical outcomes in a prospective pediatric UC cohort. Whereas the 4 markers, stool Fibrinogen, TIMP-2, PGRP-s, and MMP-8 correlate best with concurrent PUCAI and PGA scores, a 5-marker panel (Fecal calprotectin, haptoglobin, Hb, PGRP-s, and TIMP-2) best predict PGA longitudinally, while a 3-marker panel (Fibrinogen, TIMP-2, and Properdin) at baseline best predict week 4 remission. CD-Crohn’s disease, UC-ulcerative colitis, HC-healthy control, W4-week 4, W12-week 12, and W52-week52 of longitudinal follow-up.

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