Fig. 3: BS-DRL1 KO mice show genome instability. | Nature Communications

Fig. 3: BS-DRL1 KO mice show genome instability.

From: Long noncoding RNA BS-DRL1 modulates the DNA damage response and genome stability by interacting with HMGB1 in neurons

Fig. 3

a Circos plot of 3-month-old mice from the whole-genome sequencing data of 3 pairs of BS-DRL1 KO mice brain tissues. The circle plot represents rearrangements (inner arcs), copy-number alternations (inner rings) and single nucleotide polymorphisms (middle rings). In rearrangements, lines show translocation breakend (red), deletions (blue), tandem duplication (green), insertions (purple), inversions (orange). Copy-number gain and loss regions are shown in red and green. b, c Summary of the base substitute in mutations identified by whole-genome sequencing of three pairs of BS-DRL1 KO mice brain tissues. d, e ROS level of primary neurons (DIV9) from BS-DRL1 KO mice and littermate controls were measured with an oxidation-sensitive fluorescent probe DCFH-DA (Dichloro-dihydro-fluorescein diacetate). Five images were used for statistics, Data are presented as mean ± SD, *p < 0.05.

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