Fig. 6: BS-DRL1 KO mice show motor deficiency. | Nature Communications

Fig. 6: BS-DRL1 KO mice show motor deficiency.

From: Long noncoding RNA BS-DRL1 modulates the DNA damage response and genome stability by interacting with HMGB1 in neurons

Fig. 6

a, b Open field test showing significantly higher total traveling distance and more times of entry into the central zone of the arena in 6-month-old BS-DRL-1 KO mice compared to the littermate controls. Data are presented as mean ± SD. Male, n = 15:10; female, n = 9:7. *p < 0.05, **p < 0.01. c An increase of latency to fall was observed in rotarod test of 6-month-old BS-DRL-1 KO female mice compared to the littermate controls. Data are presented as mean ± SD. Male, n = 15:10; female, n = 11:7. *p < 0.05, ns not significant. d Gait analysis of 6-month-old BS-DRL-1 KO female mice. Representative example shows the percentage of stance time/stride time of four limbs. Data are presented as mean ± SD. Male, n = 15:10; female, n = 11:7. *p < 0.05, ns not significant. e Grip strength is impaired in BS-DRL-1 KO female mice compared to the littermate controls. Data are presented as mean ± SD. Male, n = 15:10; female, n = 11:7. *p < 0.05.

Back to article page