Table 3 Adverse events.
Event | IC + CRT group (n = 55), % | CRT group (n = 55), % | ||||||
|---|---|---|---|---|---|---|---|---|
Grade 1 or 2 | Grade 3 | Grade 4 | Grade 5 | Grade 1 or 2 | Grade 3 | Grade 4 | Grade 5 | |
Acute adverse event | ||||||||
Anemia | 53 (96.4) | 1 (1.8) | 0 | – | 50 (90.9) | 1 (1.8) | 0 | – |
Leukopenia | 31 (56.4) | 10 (18.2) | 2 (3.6) | – | 37 (67.3) | 6 (10.9) | 4 (7.3) | – |
Neutropenia | 18 (32.7) | 4 (7.3) | 6 (10.9) | – | 26 (47.3) | 1 (1.8) | 3 (5.5) | – |
Febrile neutropenia | 0 | 3 (5.5) | 0 | 0 | 0 | 1 (1.8) | 0 | 0 |
Thrombocytopenia | 22 (40.0) | 2 (3.6) | 0 | 0 | 15 (27.3) | 1 (1.8) | 1 (1.8) | 0 |
Hepatotoxic event | 8 (14.5) | 1 (1.8) | 0 | 0 | 15 (27.3) | 2 (3.6) | 0 | 0 |
Nephrotoxic event | 13 (23.6) | 0 | 0 | 0 | 8 (14.5) | 1 (1.8) | 0 | 0 |
Nausea/vomiting | 53 (96.4) | 0 | 0 | 0 | 50 (90.9) | 1 (1.8) | 0 | 0 |
Diarrhea | 6 (10.9) | 0 | 0 | 0 | 8 (14.5) | 0 | 1 (1.8) | 0 |
Weight loss | 32 (58.2) | 0 | 0 | 0 | 28 (50.9) | 0 | 0 | 0 |
Fatigue | 50 (90.9) | 0 | 0 | 0 | 53 (96.4) | 0 | 0 | 0 |
Fever | 17 (30.9) | 0 | 0 | 0 | 13 (23.6) | 0 | 0 | 0 |
Esophagitis | 35 (63.6) | 8 (14.5) | 0 | 1 (1.8) | 38 (69.1) | 13 (23.6) | 0 | 0 |
Pneumonitis | 30 (54.5) | 2 (3.6) | 0 | 0 | 25 (45.5) | 1 (1.8) | 0 | 1 (1.8) |
Dermatitis | 30 (54.5) | 0 | 0 | 0 | 30 (54.5) | 0 | 0 | 0 |
Cardiac | 3 (5.5) | 0 | 0 | 0 | 4 (7.3) | 0 | 0 | 0 |
Neurology | 3 (5.5) | 0 | 0 | 0 | 3 (5.5) | 0 | 0 | 0 |
Late adverse event | ||||||||
Cardiac | 5 (9.1) | 0 | 0 | 0 | 4 (7.3) | 0 | 0 | 0 |
Esophagitis | 2 (3.6) | 0 | 0 | 1 (1.8) | 3 (5.5) | 0 | 0 | 1 (1.8) |
Pneumonitis | 13 (23.6) | 0 | 0 | 0 | 11 (20.0) | 1 (1.8) | 0 | 1 (1.8) |
