Fig. 8: Schematic illustration for the mechanism of obesity-induced reduction of βFaar impairing insulin biosynthesis and exacerbated β-cells apoptosis.
From: The long non-coding RNA βFaar regulates islet β-cell function and survival during obesity in mice
During obesity, βFaar is downregulated by DNA hypermethylation, suppressing insulin biosynthesis and secretion by downregulating islet-specific gene (Ins2, NeuroD1, and Creb1) expression through sponging miR-138-5p. Moreover, reduced βFaar inhibits to recruit E3 ubiquitin ligase SMURF1, then suppressing the ubiquitination and degradation of TRAF3IP2, activing the NF-κB signal pathway, and finally inducing β-cell apoptosis.
