Fig. 1: TMPRSS2 is an androgen-regulated gene in cells from different tissues. | Nature Communications

Fig. 1: TMPRSS2 is an androgen-regulated gene in cells from different tissues.

From: The antiandrogen enzalutamide downregulates TMPRSS2 and reduces cellular entry of SARS-CoV-2 in human lung cells

Fig. 1

a LNCaP cells were incubated in hormone-depleted media for 72 h and treated with ±10 nM dihydrotestosterone (DHT) ± 10 μM bicalutamide (BIC) or enzalutamide (ENZA) for 6 h. RNA was harvested, reverse transcribed and qPCR performed to quantify TMPRSS2 expression. Mean of three independent repeats (±1 SEM). One-way ANOVA with Tukey’s multiple comparison test **** Vehicle Control (VC) v DHT – p = 8.6 × 10–11, DHT v BIC – p = 4.9 × 10–11, DHT v DHT + BIC – p = 7.3 × 10–10, DHT v ENZA – p = 4.0 × 10–11, DHT v DHT + ENZA – p = 1.0 × 10–10. b Data from T47D cells (GSE62243, N = 3)39 treated with 10 nM DHT were analysed for TMPRRS2 expression. One-tailed t-test, *p = 0.0302. Source data are provided as a Source Data file.

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