Fig. 1: Chromatin environment at the α-globin locus.
From: Reactivation of a developmentally silenced embryonic globin gene
Upper panel, Tiled-C interaction map showing interactions across the α-globin locus in definitive erythroblasts16. Lower, normalized (RPKM) ATAC-seq tracks from primary primitive (blue) and definitive (red) erythroid cells; these were merged from three independent experiments where three litters (primitive) or three fetal livers (definitive) were analyzed in total. The α-globin enhancers (R1–R4;Rm) and the flanking CTCF sites (HS-38, and HS-44;HS-48) of the α-globin gene cluster are indicated. In primitive cells, hypersensitivity is observed over the Hba-x gene; the other elements within the gene cluster are unchanged compared to definitive erythroid cells.
