Fig. 4: The ζ-globin gene remains in proximity to the α-globin superenhancer in definitive erythropoiesis.
From: Reactivation of a developmentally silenced embryonic globin gene
Normalized Capture-C data from the viewpoint of the Hba-x promoter and the Hba-a1/2 promoter (lower panels), ATAC-seq tracks are shown above for orientation. The mean, plus and minus one standard deviation (s.d.), of sliding 5 kb windows are visualized. Differential tracks (ΔCapture-C) show a subtraction (Primitive−Definitive) of the mean number of meaningful interactions per restriction fragment. Red vertical bars indicate the position of viewpoints; an ATAC-seq track from primitive erythroid cells is shown with the enhancer elements, promoters, and CTCF boundary elements denoted. Data from three independent experiments are merged. The extent of the alpha-globin TAD is indicated with a double-headed arrow.
