Fig. 8: Model of ζ-globin activation and repression.
From: Reactivation of a developmentally silenced embryonic globin gene
LRF and BCL11A both interact via the NuRD complex leading to ζ-globin hypoacetylation and silencing in definitive (adult) erythroid cells and are regulated upstream by KLF115. Pink circles represent the domain of H3K27 acetylation, green circles, and blue ovals represent transcriptional activators and repressors respectively. The yellow oval indicates a separate compartment containing the hypoacetylated region containing the ζ-globin gene. HS-39/HS-38 and HS44/48 refer to the CTCF sites known to be involved in the formation of the α-globin domain19 and the arrows indicate directionality, see main text.
