Fig. 3: Fine-mapping of 634 independent signals by credible set variants including 138 with small credible set size.

For the 424 identified eGFRcrea loci, we derived 634 independent signals by approximate conditional analyses with GCTA²⁴ and, for each signal, 99% credible sets of variants using the method by Wakefield²⁵ based on the European-only meta-analysis results (n = 1,004,040). a Distribution of the number of signals per 424 loci. b Distribution of credible set sizes for the 226 signals at novel loci. c Distribution of credible set sizes for the 408 signals at known loci. Colour in panels b and c denotes the order in which the signal appeared in the stepwise conditional analysis. Of the 634 signals, 138 were successfully fine-mapped down to a small credible set (i.e. <=5 variants) including 44 that contained exactly one variant.