Fig. 5: Association of NUDT15 diplotypes with CMV control and graft failure in patients receiving hematopoietic stem cell transplantation.

NUDT15 diplotypes (normal, intermediate, or low activity groups) in recipients and donors were classified based on the number (0: normal; 1: intermediate; 2: low) of impaired alleles (*2, *3, *4, *5) they harbored. a Incidence of CMV viremia in recipients on acyclovir prophylaxis was plotted by the combinations of NUDT15 diplotype of recipient and donor as follows: low/normal or normal/low; intermediate/intermediate; normal/intermediate or intermediate/normal; normal/normal. There were no patients with other combinations in our study cohort. P value (two-sided) was calculated using a Chi-square test. b The rate of graft failure in recipients who had CMV-seropositive donors was plotted by the NUDT15 diplotype of donors. P value (two-sided) was calculated using a Fisher’s exact test. Source data for a and b are provided as a Source Data file.