Fig. 8: SARS-CoV-2 infection targets ciliated cells in the trachea of infected Syrian golden hamsters. | Nature Communications

Fig. 8: SARS-CoV-2 infection targets ciliated cells in the trachea of infected Syrian golden hamsters.

From: SARS-CoV-2 infection induces the dedifferentiation of multiciliated cells and impairs mucociliary clearance

Fig. 8

A Immunofluorescence imaging of hamster tracheas at 4 dpi. Ciliated cells are labeled with β-tubulin IV (red), basal cells by cytokeratin-5 (yellow), and nuclei by Hoechst (blue). Representative images are shown for a mock-infected animal (left, n = 3), and SARS-CoV-2-infected animals who received a low dose (middle, n = 2) or a high dose (right, n = 2) of virus. B–D Whole-mount immunofluorescence imaging of the tracheal epithelium of mock-infected (left) or SARS-CoV-2-infected (middle and right) hamsters at 4 dpi. Labeling for the SARS-CoV-2 spike (B, green), the ciliated cell marker β-tubulin IV (C, red), or both markers (D) are shown. The tracheal epithelium obtained in the infected animal show various degrees of cilia destruction (middle, right) depending on the area.

Back to article page