Fig. 4: A model for modulation of Dcr-2’s cleavage activity by the dsRNA terminal structures and Loqs-PD.
From: Single-molecule analysis of processive double-stranded RNA cleavage by Drosophila Dicer-2
BLT dsRNAs have a higher chance to be cleaved than 3′ovr dsRNAs. A common mechanism of processive cleavage is used for both BLT and 3′ovr dsRNAs. Loqs-PD simply increases the binding opportunity for both BLT and 3′ovr dsRNAs.
