Fig. 3: Forest plots of the cohort specific and inverse-variance fixed-effect meta-analysis estimates of association between higher levels of placental DNAm with gestational age at birth and birth weight.

Estimated differences in gestational age at birth and birth weight z-scores (slope) and 95% confidence intervals (95% CI) associated with increasing levels of DNAm at A, B cg27402634, C, D cg26843110, E, F cg20340720, and G, H cg17823829. All models were adjusted for maternal age, parity, maternal education, and putative cellular heterogeneity. The slopes and 95% confidence intervals (95% CIs), represent the regression coefficients from linear models, in which gestational age (inverse normal transformed) and birth weight (z-scores) were regressed on DNAm at each CpG, while adjusting for confounders.